The following is a list of principals who have served in Kamwenja:
1924 – 1928 – Father Louis Massa
1928 – 1948 – Fr. G. Barra
1948 – 1953 – Fr. Luka
1953 – 1959 – Fr. Tarsisio Rossi
1960 – 1962 – Brother Columban
1963 – 1966 – Bro. Thomas
1967 – 1969 – Bro. Amedy Sands
1970 – 1975 – Mr. Francis Ndegwa
1976 – 1982 – Mr. Joseph B. Ndungu
1983 – 1987 – Mr. Dominic J. Owino
1988 – 1993 – Mr. Francis Mwangi
1994 June – 2002 – Mr. Michael G. Kanore
July 2002 – August 2003 – Mr. C. K. Kariuki
Sept. 2003 – December 2006 – Ms Helen Waweru
Jan. 2007 – Dec. 2007 – Mr Fredrick Wamae
Jan. 2008 – 20th Sept. 2020 – Ms. Anastasia M. Mutuku, HSC
21st Sept. 2020 – Present – Mr. Wycliffe Wafula